The Coastal Exposome: a Study of Sea Air Inhalation and Possible Links to Health

University Ghent

Status: Active, not recruiting

Conditions: Exposure; Immune Suppression

Treatments: Other: change of environment; Other: no intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT06477627

ONZ-2024-0078

Details and patient eligibility

About

The research aims to understand oceans as crucial contributors to human health in coastal environments. Oceans produce marine spray aerosols that contain a mixture of microbiota and natural biological molecules (biogenics).

Full description

The primary outcome envisioned consists of 2 goals.

1. In this study, the first objective is to determine whether the microbiota and biogenic molecules found in sea air are also found in the nasal swabs of the participants. In this way, the investigators will gain an understanding of which sea air components are inhaled by humans and how this changes over time.
2. Second, the investigators want to get an idea of whether these inhaled sea air components have an effect on certain pathways in the human body. In the in vitro study with cell lines, effects were already seen of sea air exposure on certain pathways in the body. Now the second goal of this study, is to see if changes in immunity biomarkers (IL-6, TNF-alpha, IL-10) are seen in vivo in humans. The Investigators will do this by taking VAMS blood samples from the participants.

Enrollment: 67 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• health participants between 18 and 50 years old

Exclusion criteria

• people with a medical condition
• people younger than 18 and older than 50

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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67 participants in 3 patient groups

Studygroup that will move from inland to the coast for one month

Other group

Description:

This group normally lives inland and live at the coast in august. We investigate the change to the coast environment

Treatment:

Other: change of environment

reference group coast

Other group

Description:

This group lives inland the whole year round

Treatment:

Other: no intervention

reference group inland

Other group

Description:

This group lives inland all year round.

Treatment:

Other: no intervention