The Cold Ischemia Robot-assisted Partial Nephrectomy

Sun Yat-sen University

Status: Enrolling

Conditions: Renal Function Abnormal; Renal Cell Carcinoma

Treatments: Procedure: Cold ischemia robot-assisted partial nephrectomy; Procedure: Warm ischemia robot-assisted partial nephrectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT07326280

SL-B2022-518-03

Details and patient eligibility

About

To establish evidence that cold ischemia, achieved through the use of ice slush, can improve the recovery from ischemia on the operated kidney in patients undergoing robot-assisted partial nephrectomy.

Full description

Randomly dividing the study cohorts into two groups. One group undergoing cold ischemia partial nephrectomy and the other undergoing warm ischemia partial nephrectomy. Comparing the short-term renal function recovery between the two groups.

Enrollment: 310 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

- 18 to 80 years old; 2. Intending to perform robot-assisted partial nephrectomy

Exclusion criteria

• Anesthesiologist assessment: Patient unsuitable for general anesthesia;
• Having severe cardiovascular and cerebrovascular diseases;
• horseshoe kidney;
• pregnant women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

310 participants in 2 patient groups

Cold ischemia

Experimental group

Description:

During the surgical procedure, employing ice to achieve local hypothermia in the kidneys.

Treatment:

Procedure: Cold ischemia robot-assisted partial nephrectomy

Warm ischemia

Active Comparator group

Description:

Not applying local hypothermia to the kidneys during the surgical procedure

Treatment:

Procedure: Warm ischemia robot-assisted partial nephrectomy