The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of RIF

National and Kapodistrian University of Athens

Status: Completed

Conditions: Repeated Implantation Failures; Endometrial Injury; Hysteroscopy

Treatments: Procedure: Endometrial injury

Study type: Interventional

Funder types: Other

Identifiers

NCT04597463

1811198218111982

Details and patient eligibility

About

The investigators checked the hypothesis whether endometrial injury performed during the cycle before a frozen embryo transfer in women with RIF can improve pregnancy rates

Full description

After a freeze all cycle, participants were divided in two groups: an intervention group (n=30), who underwent endometrial injury before the transfer, and a control group (n=30), who underwent no other intervention. The primary outcome was clinical pregnancy rate, while secondary clinical and laboratory parameters. Baseline and cycle characteristics were also compared between groups.

Enrollment: 60 patients

Sex: Female

Ages: 25 to 42 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Women with RIF under 42 years old
• BMI 20-30
• Normal endometrial cavity
• FSH <15 IU/L
• Absence of immunological or hematological disorder

Exclusion criteria

• women over 42 years old
• FSH>15 IU/L
• women with chronic immunological or hematological disorder
• stage III or IV of endometriosis
• women with pathology concerning the endometrial cavity
• women with a medical history of adnexectomy or oophorectomy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

Endometrial injury

Experimental group

Description:

Endometrial injury before the embryo transfer of a frozen cycle

Treatment:

Procedure: Endometrial injury