The Combination of Sperm Selection by IMSI and Hyaluronic Acid Binding Assay May Improve ICSI Outcome.

Clalit Health Services

Status: Active, not recruiting

Conditions: Fertility Issues

Treatments: Procedure: Sperm selection by IMSI; Procedure: Sperm selection by IMSI and spermslow

Study type: Interventional

Funder types: Other

Identifiers

NCT06156722

MEIRIMSIRCT

Details and patient eligibility

About

In this prospective randomized sibling-oocytes blinded study, investigators examine the combination of two sperm selection methods that logically seem to complete each other, and potentially may improve ICSI outcomes.

The methods include the selection of the optimal spermatozoa based on its morphology by IMSI, together with its physiological function of binding to HA by Spermslow (SS).

The current study compared a group of ET after sperm selection by IMSI with SS to a group of ET after sperm selection by IMSI-only without SS, and to a mixed ET group where two embryos were transferred, one after IMSI-only and the other one after IMSI with SS.

Enrollment: 189 patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

females ages 38 or younger retrieval of at least 5 mature oocytes and fresh ejaculate samples

Exclusion criteria

frozen embryos surgically extracted sperm preparations embryo-biopsy cycles

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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189 participants in 3 patient groups

The IMSI-only group

Active Comparator group

Description:

The IMSI-only group

Treatment:

Procedure: Sperm selection by IMSI

IMSI with SpermSlow group

Active Comparator group

Description:

IMSI with SpermSlow group

Treatment:

Procedure: Sperm selection by IMSI and spermslow

Mixed embryo group

No Intervention group

Description:

Mixed embryo group