The Combination Therapy of Fractional Laser and PRP Compared With Nanofat Grafting and PRP Synergy in Treating Striae Gravidarum.

Jinan University

Status and phase: Unknown; Phase 3

Conditions: Treatments of Striae Gravidarum

Treatments: Device: Fractional CO2 Laser; Procedure: Platelet-rich plasma (PRP) Injection; Procedure: Nanofat grafting

Study type: Interventional

Funder types: Other

Identifiers

NCT03328871

LXiao FirstJinanU

Details and patient eligibility

About

Nowadays, multiple treatment modalities have been applied clinically to treat striae gravidarum, such as laser therapy, microdermabrasion, platelet-rich plasma injection(PRP), etc. To some extent, these treatments can improve striae gravidarum. In this clinical trial, the investigators are going to treat striae gravidarum by using two different kinds of combination therapies. One is fractional laser and PRP injection synergy, and the other one is treated by nanofat grafting with PRP injection.

Full description

The investigators will pick out two areas of most severe striae gravidarum on a participant's abdomen. One of the areas will be treated by fractional laser once every three months for 2 times combined with PRP injection once a month for 6 times. Another area will be treated by nanofat grafting once every three months for 2 times and PRP therapy once a month for 6 times. The participants were asked to come back 1、3、6、9 months after treatment for further follow-up.

Before and after the treatment, the striae gravidarum will be assessed subjectively by satisfaction assessment, dermatoscope and ultrasound, and objectively by immunohistochemical analysis.

Enrollment: 10 estimated patients

Sex: Female

Ages: Under 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The striae gravidarum was appeared within 3 years
• Age ≤ 35 years old
• Not in lactation
• Not pregnancy within one year

Exclusion criteria

• Skin allergy
• Skin inflammation or wound
• Platelet dysfunction syndrome
• Take anticoagulant drugs
• Acute or chronic infection
• Chronic liver disease
• Photodermatosis
• Active vitiligo, psoriasis, systemic lupus erythematosus
• Other clinical trial

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Quadruple Blind

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10 participants in 2 patient groups

Fractional CO2 Laser and PRP injection

Experimental group

Description:

One of the striae gravidarum areas will be treated by fractional laser once every three months for 2 times combined with PRP injection once a month for 6 times.

Treatment:

Device: Fractional CO2 Laser

Procedure: Platelet-rich plasma (PRP) Injection

Nanofat grafting and PRP injection

Experimental group

Description:

Another area will be treated by nanofat grafting once every three months for 2 times and PRP therapy once a month for 6 times.

Treatment:

Procedure: Nanofat grafting

Procedure: Platelet-rich plasma (PRP) Injection