The Combination Therapy of Nanofat Grafting and PRP Compared With Microfat Grafting and PRP Synergy in Treating Striae Distensae

Jinan University

Status: Unknown

Conditions: Treatments of Striae Distensae

Treatments: Procedure: Platelet-rich plasma (PRP) Injection; Procedure: Nanofat grafting; Procedure: Microfat grafting

Study type: Interventional

Funder types: Other

Identifiers

NCT03807986

Xiao FirstJinanU

Details and patient eligibility

About

Striae distensae is caused by the fracture and damage of the elastic fibers and collagen fibers, which is still a difficulty to overcome. Based on the studies demonstrated that platelet-rich plasma(PRP) has positive effect on superficial scar, and nanofat and microfat are effective in treating atrophic scar. So in this clinical trial, the investigators are going to treat striae distensae by using two combination therapies. One is nanofat grafting and PRP injection synergy, and the other one is treated by microfat grafting with PRP injection.

Full description

The participants were randomly assigned into two groups. Group A is treated by nanofat grafting once every three months for 2 times combined with PRP injection once a month for 6 times. Group B will be treated by microfat grafting onceevery three months for 2 times combined with PRP injection once a month for 6 times. The participants were asked to come back 1、3、6、9 months after treatment for further follow-up.Before and after the treatment, the striae distensae will be assessed subjectively by satisfaction assessment, and objectively by ultrasound and immunohistochemical analysis.

Enrollment: 12 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The striae distensae
• Age ≤ 35 years old

Exclusion criteria

• Skin allergy
• Cicatricial diathesis
• Skin inflammation or wound
• Platelet dysfunction syndrome
• Take anticoagulant drugs
• Acute or chronic infection
• Chronic liver disease
• Active vitiligo, psoriasis, systemic lupus erythematosus

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Quadruple Blind

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12 participants in 2 patient groups

Nanofat grafting and PRP injection

Experimental group

Description:

Striae diatensae will be treated by nanofat grafting once every three months for 2 times combined with PRP injection once a month for 6 times.

Treatment:

Procedure: Platelet-rich plasma (PRP) Injection

Procedure: Nanofat grafting

Microfat grafting and PRP injection

Experimental group

Description:

Striae diatensae will be treated by microfat grafting once every three months for 2 times combined with PRP injection once a month for 6 times.

Treatment:

Procedure: Platelet-rich plasma (PRP) Injection

Procedure: Microfat grafting