The Combined Effect of 2,3-Dimercaptosuccinic Acid and Multi-Nutrients on Children in Lead Poisoning

China Medical University, China

Status: Completed

Conditions: Lead Poisoning

Treatments: Drug: 2,3-dimercaptosuccinic acid

Study type: Observational

Funder types: Other

Identifiers

NCT00374894

20032063 - 2001102049

Details and patient eligibility

About

Lead poisoning remains a common disease among children despite successful public health efforts that reduced its prevalence.Our study was designed to test the hypothesis that lead-poisoning children (BLLs:100-440µg/L) who were given DMSA and multi-nutrients would have a greater fall than children of other groups at 12 weeks of follow-up.

Sex: All

Ages: 3 to 6 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Initial BLLs 100-440µg/L
• Age 3-6y
• No more than two main residences
• House cleaned (no lead contaminated)
• Normal intake history and physical

Exclusion criteria

• Chelation in the past 12 weeks
• Concomitant Fe deficiency(ferritin<16ng/ml)
• Hemoglobin<10.5g/dL
• Medications affecting mineral metabolism