The Combined Effect of Omega-3 Fatty Acid and Vitamin D3 on Lipid Profile Levels and Oxidized Low Density Lipoprotein

Applied Science Private University

Status: Completed

Conditions: Vitamin D Deficiency

Treatments: Other: no intervention; Dietary Supplement: VD3; Dietary Supplement: VD3 and omega- 3FA; Dietary Supplement: omega 3- FA

Study type: Interventional

Funder types: Other

Identifiers

NCT04005573

DRGS-2014-2015-165-2

Details and patient eligibility

About

The combined effect of omega-3 fatty acid and vitamin D3 on lipid profile levels and oxidized low density lipoprotein: a randomized controlled trial in males and females with vitamin D deficiency

Full description

Nothing is published in the literature about the combined effect of vitamin D3 (VD3) and omega-3 fatty acids (omega-3FA) on on lipid profile levels and oxidized low density lipoprotein

This study will be conducted to investigate effect of VD3 and omega-3FA alone and with each other on lipid profile levels and oxidized low density lipoprotein in Jordanian people with vitamin D deficiency.

This randomized, controlled clinical trial will be designed to test effects of 50,000 IU VD3 weekly and 300 mg omega-3FA daily for eight weeks, separately and with each other, on on lipid profile levels and oxidized low density lipoprotein

Enrollment: 111 patients

Sex: All

Ages: 22 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Jordanian people aged 25-55 medical diagnosis of vitamin D deficiency ( VD <25 ng/ ml)

Exclusion criteria

• Subjects with previously diagnosed with any chronic disease (cardiovascular disease, osteoporosis, cancer, kidney disease, endocrine disorder, thalassemia) or has a documented history of allergic reactions to n-3FA supplementations

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

111 participants in 4 patient groups

VD3 group

Experimental group

Description:

dietary supplement : VD3 group treated with 50000 IU VD3/ week for 8 weeks

Treatment:

Dietary Supplement: VD3

omega 3- FA group

Experimental group

Description:

dietary supplement : omega 3- FA group 1000 mg wild salmon and fish oil complex (contain 300 mg of omega 3-FA) once daily for 8 weeks

Treatment:

Dietary Supplement: omega 3- FA

VD3 and omega 3 FA group

Experimental group

Description:

dietary supplement : VD3 and omega-3FA 50000 IU VD3/week for 8 weeks and 1000 mg wild salmon and fish oil complex (contain 300 mg of omega 3-FA) once daily for 8 weeks

Treatment:

Dietary Supplement: VD3 and omega- 3FA

control group

Other group

Description:

no intervention was given

Treatment:

Other: no intervention