The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria Prevention

London School of Hygiene and Tropical Medicine

Status and phase: Unknown; Phase 4

Conditions: Malaria

Treatments: Other: Indoor residual spraying with bendiocarb; Other: LLIN by universal coverage campaign

Study type: Interventional

Funder types: Other

Identifiers

NCT01697852

ITDCVP54

Details and patient eligibility

About

The study is a cluster randomised trial to compare the effectiveness of indoor residual spraying (IRS) combined with the use of long lasting insecticidal nets (LLINs) with the effectiveness of LLINs alone for preventing malaria infection and morbidity. The primary outcome measure is prevalence of parasitaemia and anaemia in children aged 0.5-10 years, measured in cross sectional surveys. Secondary outcomes include relative population density for each mosquito vector species, malaria transmission as measured by entomological inoculation rates (EIR) by mosquito vector species, monitoring of resistance markers including kdr, and user acceptability of LLINs compared with IRS.

Findings from this study are expected to inform decision making so that resource utilization can be optimised.

Enrollment: 22,300 estimated patients

Sex: All

Ages: 6 months to 14 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• resident in selected cluster (village)

Exclusion criteria

• Not resident in selected cluster (village)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

22,300 participants in 2 patient groups

LLIN plus IRS

Experimental group

Description:

LLIN by universal coverage campaign 2 rounds of indoor residual spraying with bendiocarb insecticide

Treatment:

Other: LLIN by universal coverage campaign

Other: Indoor residual spraying with bendiocarb

LLIN only

Active Comparator group

Description:

LLIN by universal coverage campaign

Treatment:

Other: LLIN by universal coverage campaign