The Comparison Between the Therapeutic Affect of Intravitreal Diclophenac and Triamcinolone in Persistent Uveitic Cystoids Macular Edema

Shahid Beheshti University of Medical Sciences

Status and phase: Unknown; Phase 1

Conditions: Uveitis; Cystoid Macular Edema

Treatments: Drug: Diclophenac; Drug: Triamcinolone

Study type: Interventional

Funder types: Other

Identifiers

NCT00893854

8727

Details and patient eligibility

About

Cystoids macular edema (CME) is one of the most common causes of low vision due to uveitis. The treatment for reducing the intra-ocular inflammation can decrease the macular edema. In some patients, CME persists even after inflammation control, and additional treatment is needed for better vision. Oral steroid, periocular and intravitreal Triamcinolone are the principles in treatment, but some complications like cataracts and increased ocular pressure have been seen. Diclophenac is a non-steroid anti-inflammatory drug that improves the vision and decreases the macular thickness by slowing down the prostaglandin E2 (PGE2) ending in vascular endothelial growth factor (VEGF) inhibition. In this study, the investigators are going to compare the therapeutic affect of intravitreal Diclophenac and Triamcinolone in persistent uveitic cystoids macular edema. Since diclophenac is a cheap and accessible drug in all curative centers it could be applied instead of Triamcinolone.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• cystoids macular edema which is diagnosed by OCT and flurocein angiography
• 5/200 < Visual acuity < 20/50
• resistance to routine treatment (oral treatment, periocular injection)

Exclusion criteria

• history of retinal disease cause macular edema like diabetes
• arterial occlusion
• monocular patients
• patients candidate for intra-ocular operation
• history of glaucoma or ocular hypertension
• any cataract that would interfere with OCT

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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0 participants in 2 patient groups

Diclophenac

Experimental group

Treatment:

Drug: Diclophenac

Triamcinolone

Experimental group

Treatment:

Drug: Triamcinolone