The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Robotic-assisted Laparoscopic Radical Prostatectomy Under Sevoflurane, Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

Yonsei University

Status: Completed

Conditions: Robotic-assisted Laparoscopic Radical Prostatectomy

Treatments: Drug: sevoflurane; Drug: propofol and remifentanil; Drug: desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT03539003

4-2018-0296

Details and patient eligibility

About

The purpose of this study is to compare the changes of QTc, Tp-e interval, and Tp-e/QT ratio, Tp-e/QTc ratio on the ECG during robotic-assisted laparoscopic radical prostatectomy under sevoflurane, desflurane and total intravenous anesthesia

Enrollment: 69 patients

Sex: Male

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. ASA class I-III
2. patients undergoing elective robot-assisted laparoscopic radical prostatectomy
3. adult (≥19 years old)

Exclusion criteria

1. emergency surgery
2. preoperative QTc prolongation
3. Cardiac disease (unstable angina, congestive heart failure, valvular heart disease)
4. uncontrolled hypertension (DBP >110 mmHg)
5. Patients who take beta blocker
6. Ventricular conduction abnormality
7. Hepatic or renal failure
8. Drug hyperactivity
9. patients unable to understand informed consent (foreigner, illiteracy..)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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69 participants in 3 patient groups

sevoflurane (Group S)

Experimental group

Description:

general anesthesia with sevoflurane

Treatment:

Drug: sevoflurane

desflurane (Group D)

Active Comparator group

Description:

general anesthesia with desflurane

Treatment:

Drug: desflurane

total intravenous anesthesia (Group T)

Active Comparator group

Description:

general anesthesia with total intravenous anesthesia

Treatment:

Drug: propofol and remifentanil