The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Living Donor Liver Transplantation Under Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

Yonsei University

Status: Completed

Conditions: Liver Cirrhosis(Who Will Undergo Planed Liver Transplantation)

Treatments: Drug: inhalation (desflurane) group; Drug: total intravenous (propofol) anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT03864276

4-2018-1164

Details and patient eligibility

About

Prolonged corrected QT interval (QTc) has been observed in about half of patients with liver cirrhosis. Marked prolongation of QTc (ie, 500 msec) has been considered to be a risk factor for fatal ventricular arrhythmia, such as torsade de pointes,7,8 which has been reported in liver transplantation (LT) surgery. In a previous study, prolonged QTc interval ( 500 msec) was frequently observed throughout the procedure of LT, even among patients with baseline QTc 440 msec. Therefore, it is important to optimize electrolyte balance and hemodynamic status to reduce greater risk of perioperative arrhythmias.

The investigators hypothesized that the change of QTc interval might be differ according to method of general anesthesia (inhalation agent vs. intravenous agent).

Enrollment: 120 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with liver cirrhosis who will undergo planned liver transplantation

Exclusion criteria

• 1. emergent liver transplantation
• 2. unstable angina
• 3. recent MI(Myocardial Infarction)
• 4. uncontrolled hypertension (diastolic BP > 110mmHg)
• 5. implantable cardiac defibrillator
• 6. severe obesity (BMI>30kg/m2)
• 7. allergy to propofol

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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120 participants in 2 patient groups

inhalation anesthesia (desflurane) group

Experimental group

Description:

Anesthesia is induced and maintained with desflurane and sufentanil

Treatment:

Drug: inhalation (desflurane) group

Total intravenous anesthesia (propofol) group

Experimental group

Description:

Anesthesia is induced and maintained with propofol and sufentanil

Treatment:

Drug: total intravenous (propofol) anesthesia