The Comparison of Desflurane and Sevoflurane on Postoperative Recovery and Hepatic Function of Biliary Atresia Patients During Kasai Operation

Yonsei University

Status: Completed

Conditions: Kasai Operation; Biliary Atresia

Treatments: Drug: desflurane anesthetics; Drug: sevoflurane anesthetics

Study type: Interventional

Funder types: Other

Identifiers

NCT01443572

4-2011-0436

Details and patient eligibility

About

Biliary atresia (BA) is a perinatal disease of unclear etiology, characterized by inflammation and obliteration of intrahepatic and extrahepatic bile ducts, leading to cholestasis and cirrhosis. Kasai operation remains as the first line operative treatment in BA. In the previous studies, inhalation anesthetics might induce liver damage. The choice of inhalation anesthetic that minimally affects hepatic function is important. Therefore, the purpose of this study is to compare the postoperative recovery and hepatic function between desflurane and sevoflurane, two most frequently used inhalational anesthetics in patients undergoing Kasai operation.

Enrollment: 40 patients

Sex: All

Ages: Under 1 year old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with biliary atresia undergoing Kasai operation

Exclusion criteria

• patients with congenital anomalies at major organs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

desflurane group

Experimental group

Treatment:

Drug: desflurane anesthetics

sevoflurane group

Active Comparator group

Treatment:

Drug: sevoflurane anesthetics