The Comparison of Dexmedetomidine and Midazolam for the Sleep in Intensive Care Unit

Seoul National University

Status: Terminated

Conditions: Delirium; Sleep Arousal Disorders; Poor Quality Sleep; Sleep Deprivation

Study type: Observational

Funder types: Other

Identifiers

NCT01966315

B-1307/212-010

Details and patient eligibility

About

The investigators are going to compare the sleep quality and quantity between dexmedetomidine group and midazolam group using 24 hour polysomnography in critically ill patients. And the investigators also compare the incidence of delirium between the two groups.

Full description

Sleep is very important for cognitive and immune function. However, patients in intensive care unit (ICU) have a very poor sleep.

Almost all ventilated patients in intensive care unit (ICU) take a sedative drug. In Korea, most commonly used sedative drugs are dexmedetomidine and midazolam.

The investigators are going to compare the sleep quality and quantity between dexmedetomidine group and midazolam group using 24 hour polysomnography. And the investigators also compare the incidence of delirium between the two groups.

Enrollment: 5 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• sedation patients with dexmedetomidine or midazolam
• over 18 years old

Exclusion criteria

• Neurologic disease (stroke, seizure, dementia, hypoxic brain damage)
• Brain infection
• Alcoholics
• Major Depression Disorder, Schizophrenia, Anxiety disorder
• Hearing loss

Trial design

5 participants in 2 patient groups

Dexmedetomidine group

Description:

Dexmedetomidine group is the patients who sedated with dexmedetomidine in intensive care unit. We will randomly allocate using www.randomizer.org. They will sedate at the level of RASS -2. The dose of dexmedetomidine will be 0.2-0.7ug/kg/hr.

Midazolam group

Description:

Midazolam group is the patients who sedated with midazolam in intensive care unit. We will randomly allocate using www.randomizer.org. They will sedate at the level of RASS -2. The dose of midazolam will be 0.05-0.1 mg/kg/hr.