The Comparison of PYY, Ghrelin, GLP1, Glucose Level, Level of Satiety, and Ad Libitum Intake in Obese and Non-Obese Patients After Breakfast With Balanced Macronutrient Composition

University of Indonesia (UI)

Status: Completed

Conditions: Ghrelin; VAS of Hunger; VAS of Satiety; Gut Hormones; Obesity; PYY; Appetite; GLP - 1

Treatments: Behavioral: Diet with balance composition to know the effect of a meal to gut hormones in obese and non obese women

Study type: Interventional

Funder types: Other

Identifiers

NCT03701503

GuthormoneOB-NonOB

Details and patient eligibility

About

Obesity can occur due to an imbalance of energy. This energy balance is greatly influenced by hunger and satiety. Obese person cannot resist hunger, while non obese can control hunger. Gut hormones, such as PYY and ghrelin, are associated with appetite and satiety control. This study's objective is to compare the effect of breakfast with balance composition on gut hormones, glucose and ad libitum intake four hours after breakfast between obese and non obese..

The research methodology was used a clinical trial with 18 obese women and 22 non obese women participants. Subjects were given a balance breakfast (protein 12,4%, carbohydrate 68,2%, fat 22,6%). Gut hormones (PYY, Ghrelin, GLP -1) level , Glucose level and satiety level were measured at 0, 15, 60, 120, and 180 minutes after breakfast. Ad libitum meal was given four hours after breakfast and measured after.

Enrollment: 40 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 25 - 30 (for obese am)
• BMI 18,5 - 23 (for NON- obese am)
• with stable body weight within the last 6 months (body weight change less than 4 kg)
• normal blood glucose level.

Exclusion criteria

• Patients who never had breakfast
• patients in weight loss program
• patients consuming lipid-absorption inhibitor or appetite-suppressing drugs
• patients that have had gastrointestinal tract resection.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Obese

Experimental group

Description:

Women age 20-40, with BMI ≥ 25-35 kg/m2 Given a balanced breakfast (Protein 12,4%, carbohydrate 68,2%, fat 22,6%) with calories according to their energy requirement,which is calculated by adding basal metabolic rate (BMR) with additional energy from physical activity. Participants' blood was taken before intervention, and 15, 60, 120, and 180 minutes after intervention, then examined in laboratory to measure every outcome. After 4 hours, participants were given ad libitum meal. After the participants done eating, the calorie in meal taken by participants was measured.

Treatment:

Behavioral: Diet with balance composition to know the effect of a meal to gut hormones in obese and non obese women

Non Obese

Active Comparator group

Description:

Women age 20-40, with BMI 18,5-23 kg/m2 Given a balanced breakfast (Protein 12,4%, carbohydrate 68,2%, fat 22,6%) with calories according to their energy requirement,which is calculated by adding basal metabolic rate (BMR) with additional energy from physical activity. Participants' blood was taken before intervention, and 15, 60, 120, and 180 minutes after intervention, then examined in laboratory to measure every outcome. After 4 hours, participants were given ad libitum meal. After the participants done eating, the calorie in meal taken by participants was measured.

Treatment:

Behavioral: Diet with balance composition to know the effect of a meal to gut hormones in obese and non obese women