The Comparison of Uniportal and Tubeless Video Assisted Thoracic Surgery and Transbronchial Lung Cryobiopsy in the Diagnosis of Interstitial Lung Disease

Guangzhou Institute of Respiratory Disease

Status: Unknown

Conditions: Surgical Lung Biopsy; Transbronchial Lung Cryobiopsy; Interstitial Lung Disease

Treatments: Diagnostic Test: lung biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT03958162

TS20181008

Details and patient eligibility

About

To compariing the uniportal and tubeless video assisted thoracic surgery and trnsbronchial lung cryobiopsy within the multidisciplinary discussion context in the diagnosis of interstitial lung disease，and assess the safety and cost-effectiveness. This is a prospective control trial.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 18 yrs ≤ age<75yrs
2. Patients diagnosed as interstitial lung disease with comprehensive clinical data (including history, serological test, spirometry test and high resolution computed tomography)
3. Further pathological data was still required after multidisciplinary discussion.

Exclusion criteria

1. Severe pulmonary dysfunction: forced vital capacity (FVC) ≤65% or carbon-monoxide diffusion coefficient (DLco) ≤45% of predicted value
2. Pulmonary hypertension: An estimated systolic pulmonary artery pressure>50mmHg on echocardiography
3. Abnormal coagulation parameters or thrombocytopenia (<50*109/L)
4. Severe comorbidities leading to inoperable condition
5. Patients cannot give consent or refuse biopsy

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

uniportal and tubeless video assisted thoracic surgery

Experimental group

Description:

lung biospy by the uniportal and tubeless video assisted thoracic surgery

Treatment:

Diagnostic Test: lung biopsy

transbronchial lung cryobiopsy

Experimental group

Description:

transbronchial lung cryobiopsy

Treatment:

Diagnostic Test: lung biopsy