The Compliance of DAPT and Statins on Clinical Outcomes in Percutaneous Coronary Intervention Patients (CPPCI)

Samsung Medical Center

Status: Completed

Conditions: Persistence, Medication; Percutaneous Coronary Intervention; Adherence, Medication; Platelet Aggregation Inhibitors; Hydroxymethylglutaryl-coa Reductase Inhibitors; Compliance, Medication

Treatments: Drug: DAPT, Statin

Study type: Observational

Funder types: Other

Identifiers

NCT03785509

SMC 2017-04-014-001

Details and patient eligibility

About

A nationwide retrospective cohort study. To investigate the real world medication compliance and the relation with clinical outcomes.

The persistence and compliance to dual anti-platelet therapy(DAPT) and dyslipidemia agents are important for the patients undergoing percutaneous coronary intervention. But, the discontinuation and compliance rate are unknown in the real world setting.

Full description

A nationwide retrospective cohort study. The persistence and compliance to dual anti-platelet therapy(DAPT) and dyslipidemia agents are important for the patients undergoing percutaneous coronary intervention. The discontinuation and uncompliance may increase a risk. But, the discontinuation and compliance rate are not well known in the real world patients undergoing bare metal stents(BMS) and drug eluting stents(DES) insertion.

To investigate the real world medication compliance and the relation with clinical outcomes, administrative claim data was extracted from the Korean National Healthcare Insurance(KNHI) database.

All Korean patient date undergoing PCI from January 1, 2011 to December 2011 is extracted. 5 year clinical outcomes are investigated.

Primary outcomes are the MACE including all-cause death, revascularization, critically ill status, and stroke) classified by the medication compliance. Medication complinace is measured by proportion of days covered(PDC)

Secondary outcomes are the patterns of medication persistence and its outcomes to understand critical points.

Enrollment: 47,291 patients

Sex

Volunteers: No Healthy Volunteers

Inclusion criteria

1. All claim of percutaneous coronary intervention using stent in the National Healthcare Insurance Service of Korea between January 1st 2011 and December 31st, 2011

Exclusion criteria

1. No use of stents
2. Stent not classified into DES or BMS
3. Use of DES and BMS together at the same initial day