The Copmparison of Accuracy of PtcCO2 and in PetCO2 in COPD Patients

Guangzhou Medical University

Status: Unknown

Conditions: COPD

Study type: Observational

Funder types: Other

Identifiers

NCT04051931

2019-27

Details and patient eligibility

About

The pathophysiological characteristics of COPD is irreversible airflow restriction which may influence the gas exchange and cause the abnormal PaO2 and PaCO2. Assessment of the partial arterial pressure of carbon dioxide (PaCO2 ) is the 'gold standard' for the evaluation of the adequacy of alveolar ventilation.Method used mostly nowadays : arterial puncture which is accurate but is invasive 、painful、 non-dynamic and there is risk of infection and tissue、nerve damage. Noninvasive measurement methods (Most commonly used)： end-tidal CO2（ ETCO2）、 transcutaneous CO2(TcCO2). They all can monitor the PaCO2 dynamically、 noninvasively, but is existence of controversy of the accuracy. So the investigators want to compare the accuracy of these two noninvasive methods for assessment of PaCO2.

Enrollment: 100 estimated patients

Sex: All

Ages: 20 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD patients

Exclusion criteria

• hemodynamics is unstable;
• any other lung disease despite COPD；
• other diseases influencing experiments: Cognitive impairment disease、 mouth and nose trauma.

Trial design

100 participants in 2 patient groups

stable COPD group

Description:

include COPD patients with stable state

AECOPD group

Description:

include COPD patients with acute exacerbation