The Core Body Temperature Rhythms: Distinguishing MCS From UWS

Jing Wang

Status: Completed

Conditions: Disorders of Consciousness

Study type: Observational

Funder types: Other

Identifiers

NCT02930213

CX2014128

Details and patient eligibility

About

In this study, the core body temperature of 7 disorders of consciousness ( DOC ) patients were measured every 2 hour for 168 h .

Full description

Living beings have multicomponent biological rhythms. There was a research recorded 24-h virations in electroencephalographic patterns. In normal subjects, the circadian rhythms of core body temperature is close to 24 h. When the interference of environmental and mental elements were eliminated, circadian rhythm shows the endogenous circadian rhythm of body acquiescently (>24h ), which is also called free-running period.

Measuring the continuous external auditory canal temperature of 4 unresponsive wakefulness syndrome (UWS) and 3 minimally conscious state(MCS) on the fluorescent lamp surrounding every 2 hours for 168 hours starting at 00:00 on the first day to address circadian capabilities.

Researchers expected to see the difference between MCS and UWS.

Enrollment: 7 patients

Sex: All

Ages: 39 to 69 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients in minimally conscious state
• patients with stable condition
• patients free of sedative drugs and Na+ or Ca++ blockers (e.g., carbamazepine) or NMDA receptor antagonist (e.g., dextromethorphan)

Exclusion criteria

• premorbid neurology antecedent
• patients in coma or vegetative state
• patients < 1 months after the acute brain injury