The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

Jinhua Central Hospital

Status: Completed

Conditions: Critically Ill

Study type: Observational

Funder types: Other

Identifiers

NCT01344265

zh_zhang1984

Details and patient eligibility

About

The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.

Enrollment: 46 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• critically ill patients who required hemodynamic monitoring using PiCCO

Exclusion criteria

• patients with renal dysfunction
• those older than 80 years
• pregnant women

Trial design

46 participants in 1 patient group

consecutive patients

Description:

there is only one group in our study