The Correlation Between Cotinine and Postoperative Acute and Chronic Pain After Hysterectomy

Mustafa Kemal University

Status and phase: Unknown; Phase 4

Conditions: Chronic Pain, Acute Pain, Cotinine, Hysterectomy

Treatments: Device: measuring cotinine level

Study type: Interventional

Funder types: Other

Identifiers

NCT04274673

2017/181

Details and patient eligibility

About

It is known that there is an association between smoking and acute/chronic pain. But it is so difficult to assess this relation with asking questions to the patients in the preoperative period. Because of that we want to measure the levels of the cotinine in the urine and later assess the correlation with acute and chronic pain in hysterectomy patients.

Full description

It is well-known that smoking is very common in the public. The chronic pain after hysterectomy is 20-40%. The open abdominal hysterectomy ratio is 75% of all hysterectomy operations in our country. We know that the reasons of postoperative acute and chronic pain is multifactorial. One of them is smoking which affects the postoperative pain. The best way of measuring the level of cotinine is assesing the urine of the patient. We collect the first urine after induction.

In this study, we aimed to investigate the correlation between the levels of urine cotinine and the acute and chronic postoperative pain in hysterectomy patents.

Enrollment: 158 estimated patients

Sex: Female

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II
• Open abdominal hysterectomy patients

Exclusion criteria

• Chronic pain
• Chronic pain killer users
• Axis I psychiatric disease
• Liver disease
• Renal disease
• Drug allergy

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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158 participants in 3 patient groups

low (less 10ng/dl)

Other group

Description:

Patients who have low cotinine levels (less 10ng/dl)

Treatment:

Device: measuring cotinine level

medium (10-500ng/dl)

Other group

Description:

Patients who have medium cotinine levels (less 10-500ng/dl)

Treatment:

Device: measuring cotinine level

high (more 500ng/dl)

Other group

Description:

Patients who have high cotinine levels (less 10-500ng/dl)

Treatment:

Device: measuring cotinine level