The Correlation Between Gut Microbiome/Metabolite and End Stage Renal Disease (ESRD)

China Agricultural University

Status

Completed

Conditions

Kidney Failure, Chronic

Treatments

Other: No interventions, questionnaire, collect specimen

Study type

Observational

Funder types

Other

Identifiers

NCT03010696

CAUPCKD-01

Details and patient eligibility

About

The purpose of this study is to investigate the differences of gut Microbiome/Metabolite between ESRD patients and healthy subjects. Two hundred and twenty three hemodialysis patients and 70 healthy subjects are recruited, and a cross-sectional study is performed.

Enrollment

293 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

For Healthy Subjects

Inclusion Criteria:

Age over 18 years old
Liver and kidney function is normal
18.5≤BMI≤29.9
Agree to sign the informed consent form

Exclusion Criteria:

Diagnosed as Metabolic syndrome
Diagnosed as Cirrhosis
Diagnosed as kidney disease
Taking fermented food (live lactic acid bacteria drinks, cheese, yogurt, probiotic products, etc.) within 14 days before the study
Taking antibiotics or antifungal drugs within 30 days before the study

For ESRD patients

Inclusion criteria:

Age over 18 years old
Patients who diagnosed as ESRD with hemodialysis
Fixed hemodialysis cycle (average 3 times a week)
Agree to sign the informed consent form

Exclusion criteria:

Taking antibiotics or antifungal drugs within 30 days before the study
Taking fermented food (live lactic acid bacteria drinks, cheese, yogurt, probiotic products, etc.) within 14 days before the study
Reasercher are not sure whether the subjects are willing or able to complete the study
Subject participated in other research projects within two months before the study