The Correlation Between Iodine and Selenium Status in Pregnancy and Risk of Thyroid Disease

Rongrong Li

Status: Unknown

Conditions: Selenium Deficiency in Pregnancy; Iodine Deficiency in Pregnancy; Selenium Excess in Pregnancy; Iodine Excess in Pregnancy

Treatments: Other: Not applicable (for observational studies)

Study type: Observational

Funder types: Other

Identifiers

NCT03761602

ISCMS

Details and patient eligibility

About

Two hundred and ninety pregnant women with gestational age less than 20 weeks will be recruited in this study. Selenium and iodine conditions, and risk of thyroid disease will be monitored until termination of pregnancy, with pregnancy outcomes recorded.

Full description

The study will recruit 290 pregnant women with gestational age less than 20 weeks. Iodine and selenium condition will be evaluated through dietary recall (on base of Chinese food ingredient information) and biochemical examinations (serum iodine concentrations, urinary iodine concentrations, serum selenium concentrations, etc). The nutritional status of iodine and selenium will be monitored and followed up for all the included subjects throughout the pregnancy. The information of thyroid function and level of anti-TPO and anti-TG will be collected. And all the complications (especially thyroid disease) in pregnancy will also be recorded. All pregnant women will be followed up until the termination of pregnancy, with pregnancy outcomes recorded.

Enrollment: 290 estimated patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical confirmation of being pregnant.
• Being within less than 20 weeks of gestationa.

Exclusion criteria

• Being pregnant but over 20 weeks of gestationa.
• Mentally or psychologically unstable.

Trial design

290 participants in 3 patient groups

Proper selenium and iodine condition

Description:

The subjects should have proper dietary intake of selenium and iodine, according to Chinese Dietary Reference Intakes (DRIs) (intake of selenium 65μg/d and iodine 230 μg/d). The Serum iodine concentration are 45-92μg/L，and the urinary I/Cr 150-249μg/g Cr. The Serum selenium concentrations are 18-40μg/L.

Treatment:

Other: Not applicable (for observational studies)

Excessive selenium or iodine condition

Description:

The subjects have excessive dietary intake of selenium and iodine, usually more than 2 times of DRIs. The Serum iodine concentration are more than 100μg/L，and the urinary I/Cr more than 300μg/g Cr. The Serum selenium concentrations are more than 40μg/L.

Treatment:

Other: Not applicable (for observational studies)

Insufficient selenium or iodine condition

Description:

The subjects have insufficient dietary intake of either selenium or iodine, compared with DRIs. The Serum iodine concentration are less than 45μg/L，and the urinary I/Cr less than150μg/g Cr. The Serum selenium concentrations are less than 18μg/L.

Treatment:

Other: Not applicable (for observational studies)