The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

Far Eastern Memorial Hospital

Status: Completed

Conditions: Kidney Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT00632892

96013

Details and patient eligibility

About

Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM. Therefore, how to prevent CMIN is always one of the hot topics concerned by nephrologists, cardiologists, and radiologists.

The present study is aimed to determine the norepinephrine concentration, oxidative markers, and tubular damage markers in the urine samples of patients undergoing intravenous pyelography (IVP).

The working hypothesis is high-osmolarity contrast media (HOCM) causes more oxidative stress and greater tubular damage than iso-osmolarity contrast media (IOCM).

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Adult patients (> 18 years old)
2. Undergoing IVP with an appropriate medical indication
3. Signing informed consent

Exclusion criteria

1. Without signing informed consent