The Correlation Between the n-6:n-3 Ratio and Inflammatory Markers in Small for Gestational Age (SGA) Infants Compared With Appropriate for Gestational Age (AGA) Infants

Tel Aviv Sourasky Medical Center

Status

Unknown

Conditions

Appropriate for Gestational Age Infants

Small for Gestational Age Infants

Treatments

Procedure: Blood test

Study type

Observational

Funder types

Other

Identifiers

NCT02887664

0285-16-TLV-DM

Details and patient eligibility

About

Numerous studies have recommended the use of n-3 PUFA supplementation during human pregnancy and lactation for the prevention of preterm birth, beneficial effects on fetal development, visual and cognitive development and other functional outcomes of the infants.

The aim of the present study is to assess the correlation between ratio of n-3:n-6 fatty acid and inflammation markers in SGA infants compared with appropriate for gestational age (AGA) infants. The investigators hypothesize that in SGA infants n-3 and n-6 fatty acid concentrations in cord blood will differ from those observed in AGA and might correlate with the level of circulating mediators.

Enrollment

60 estimated patients

Sex

Female

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Mothers of SGA infants ( above 35 week of gestation)
Mothers of term and near-term AGA infants

Exclusion criteria

Maternal chronic diseases, smoking, diabetes, alcohol use, pregnancy-associated hypertension and pre-eclampsia
Neonatal depression
Congenital malformations
Intrauterine infections
Chromosomal aberrations
Mothers interested in cord blood banking