The Crosstalk Between Calcium-sensing Receptor Signaling and Endocannabinoid System in Primary Hyperparathyroidism (Targeting CaSR)

Insel Gruppe AG, University Hospital Bern

Status: Completed

Conditions: Primary Hyperparathyroidism

Study type: Observational

Funder types: Other

Identifiers

NCT03831620

2018-02218

Details and patient eligibility

About

Despite the strong association of hyperparathyroidism with arachidonic acid related lipid signals, little research has been performed over the years. A better understanding of the link between arachidonic acid remodeling, prostaglandin and endocannabinoid production with primary hyperparathyroidism in primary tissue/cells might open up new avenues for biomarker and thus to a potential therapeutic target.

Arachidonic acid remodeling might also have an impact on depression and elevated cytokines in patients with primary hyperparathyroidism. The investigators therefore will assess the correlation between postoperative improvement of PHQ-9 and cytokine levels with arachidonic acid remodeling.

Enrollment: 90 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Primary hyperparathyroidism with planned surgery
• Written informed consent

Exclusion criteria

• Age <18 years
• Secondary/tertiary hyperparathyroidism
• Renal insufficiency
• Participant is pregnant
• Participant is incapable of giving an informed consent