The Daytime Circadian Rhythm in Exhaled Volatile Organic Compounds in People Living Without and Diabetes (VOCircle)

University of Bern

Status

Enrolling

Conditions

Diabetes Mellitus

Treatments

Other: Standardized meal

Study type

Observational

Funder types

Other

Identifiers

NCT05984979

VOCircle

Details and patient eligibility

About

Exhaled volatile organic compounds will be measured during daytime with the goal to identifying circadian variability. The study incudes three subgroups: people without diabetes, people with type 1 diabetes, and people with type 2 diabetes. A total of 60 people will be recruited for the study.

Enrollment

60 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

Subgroup 1:

Age 18 or older
HbA1c below 6.5%
Written informed consent

Subgroup 2:

Age 18 or older
T1D (Type 1 diabetes) with MDI (multiple daily injection) or CSII (Continuous subcutaneous insulin infusion therapy) therapy >1 year
Written informed consent

Subgroup 3

Age 18 or older
T2D (Type 2 diabetes) with oral antidiabetic medication or insulin therapy
Written informed consent

Exclusion criteria

Pregnancy or breastfeeding
Smoking (last cigarette less than 6 months ago)
Any chronical lung and intestinal disease diagnosis (such as intestinal bowel disease (IBD); asthma; COPD (chronic obstructive pulmonary disease); lung cancer, …)
Coeliac disease
Lactose and fructose intolerance
Any acute disease diagnosis (such as viral or bacterial infection)
Drinking habit of more than four units of alcohol per day
Current inhaled medicines treatments
Antibiotic treatment in the previous 4 months