The Desensitising Effect of Nanosilver Fluoride in Molar-Incisor Hypomineralisation

Alexandria University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Hypersensitivity; Molar Incisor Hypomineralization

Treatments: Drug: Nanosilver fluoride; Device: Low-level laser therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT06348849

0797-11/2023

Details and patient eligibility

About

The aim of the current study is to assess the desensitising effect of nanosilver fluoride on first permanent molars (FPMs) in patients with MIH in comparison to low-level laser therapy.

Enrollment: 120 patients

Sex: All

Ages: 7 to 10 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The presence of at least one hypersensitive first permanent molar in MIH patient (using the Schiff Cold Air Sensitivity Scale (SCASS)).
• Completion of an informed consent to participate in the study.

Exclusion criteria

• Hypomineralised molars resulting from other medical conditions, such as enamel malformations associated with syndromes, dental fluorosis, enamel hypoplasia, amelogenesis imperfecta, and dental caries.
• The presence of active tooth decay or defective restorations in the tooth under examination which can confound the aetiology of hypersensitivity with pulpitis.
• The presence of pulpal symptoms.
• Having undergone any professional desensitising treatment in the previous 6 months.
• Having used a desensitising paste other than habitual toothpaste in the previous 3 months.
• Use of anti-inflammatory drugs or analgesics at the time of recruitment.
• Allergy or sensitivity to silver or any of the materials included in the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 2 patient groups

Low-level laser therapy

Active Comparator group

Description:

These hypersensitive molars with MIH will receive low-level laser therapy.

Treatment:

Device: Low-level laser therapy

Nanosilver fluoride

Experimental group

Description:

These hypersensitive molars with MIH will receive nanosilver fluoride treatment.

Treatment:

Drug: Nanosilver fluoride