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The Detection Of Circulating Tumor Cells (CTC) In Patients With NSCLC Undergoing Definitive Radiotherapy Or Chemoradiotherapy

Abramson Cancer Center at Penn Medicine logo

Abramson Cancer Center at Penn Medicine

Status

Completed

Conditions

Non-small Cell Lung Cancer

Treatments

Radiation: Radiotherapy

Study type

Observational

Funder types

Other

Identifiers

NCT02135679
UPCC 12512

Details and patient eligibility

About

CTC levels collected pre-surgery will be correlated with pathological samples.

Full description

Patients with NSCLC who undergo radiation as part of a definitive course of treatment will be enrolled. Blood collections will be obtained before, during, and after radiotherapy. We will collect demographic and treatment data and explore & describe the pattern of CTC detection in all patients

Enrollment

204 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

  • Patients with biopsy-proven NSCLC who are undergoing definitive radiotherapy as a part of their treatment regimen.
  • Age 18 or older
  • Signed informed consent
  • Patients who are incapable of providing informed consent are excluded from participating in this study.

Trial design

204 participants in 7 patient groups

Cohort 1
Description:
Patients with early stage NSCLC undergoing stereotactic radiotherapy
Treatment:
Radiation: Radiotherapy
Cohort 2
Description:
Patients with locally advanced NSCLC undergoing standard chemoradiotherapy
Treatment:
Radiation: Radiotherapy
Cohort 3
Description:
Patients with stage I-III NSCLC undergoing standard, fractionated radiotherapy alone
Treatment:
Radiation: Radiotherapy
Cohort 4
Description:
Patients with locally advanced NSCLC undergoing standard chemoradiotherapy with the novel signal transduction inhibitor, nelfianvir.
Treatment:
Radiation: Radiotherapy
Cohort 5
Description:
Patients with resectable stage IIIa NSCLC undergoing pre-operative chemoradiotherapy
Treatment:
Radiation: Radiotherapy
Cohort 6
Description:
Patients with suspected (no tissue diagnosis) early stage NSCLC undergoing stereotactic radiotherapy
Treatment:
Radiation: Radiotherapy
Cohort 7
Description:
Patients with locally advanced NSCLC undergoing stereotactic radiotherapy followed by concurrent mediastinal chemoradiotherapy
Treatment:
Radiation: Radiotherapy

Trial documents
1

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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