The Detection Of Circulating Tumor Cells (CTC) In Patients With NSCLC Undergoing Definitive Radiotherapy Or Chemoradiotherapy

Abramson Cancer Center at Penn Medicine

Status: Completed

Conditions: Non-small Cell Lung Cancer

Treatments: Radiation: Radiotherapy

Study type: Observational

Funder types: Other

Identifiers

NCT02135679

UPCC 12512

Details and patient eligibility

About

CTC levels collected pre-surgery will be correlated with pathological samples.

Full description

Patients with NSCLC who undergo radiation as part of a definitive course of treatment will be enrolled. Blood collections will be obtained before, during, and after radiotherapy. We will collect demographic and treatment data and explore & describe the pattern of CTC detection in all patients

Enrollment: 204 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients with biopsy-proven NSCLC who are undergoing definitive radiotherapy as a part of their treatment regimen.
• Age 18 or older
• Signed informed consent
• Patients who are incapable of providing informed consent are excluded from participating in this study.

Trial design

204 participants in 7 patient groups

Cohort 1

Description:

Patients with early stage NSCLC undergoing stereotactic radiotherapy

Treatment:

Radiation: Radiotherapy

Cohort 2

Description:

Patients with locally advanced NSCLC undergoing standard chemoradiotherapy

Treatment:

Radiation: Radiotherapy

Cohort 3

Description:

Patients with stage I-III NSCLC undergoing standard, fractionated radiotherapy alone

Treatment:

Radiation: Radiotherapy

Cohort 4

Description:

Patients with locally advanced NSCLC undergoing standard chemoradiotherapy with the novel signal transduction inhibitor, nelfianvir.

Treatment:

Radiation: Radiotherapy

Cohort 5

Description:

Patients with resectable stage IIIa NSCLC undergoing pre-operative chemoradiotherapy

Treatment:

Radiation: Radiotherapy

Cohort 6

Description:

Patients with suspected (no tissue diagnosis) early stage NSCLC undergoing stereotactic radiotherapy

Treatment:

Radiation: Radiotherapy

Cohort 7

Description:

Patients with locally advanced NSCLC undergoing stereotactic radiotherapy followed by concurrent mediastinal chemoradiotherapy

Treatment:

Radiation: Radiotherapy