The Diagnosis of Beta-lactam Hypersensitivity in Thailand

Chulalongkorn University

Status: Completed

Conditions: Penicillin Allergy; Beta Lactam Adverse Reaction; Aminopenicillin Allergy

Study type: Observational

Funder types: Other

Identifiers

NCT01667055

Chula-ARC 002/12

Details and patient eligibility

About

The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand. We hypothesize that only minority of patients with such a history are truly allergic.

Full description

Patients with a history of beta-lactam hypersensitivity will be evaluated by the standard skin test reagents (major and minor determinants of penicillin, amoxicillin, and clavulanic if applicable), and intravenous forms of beta-lactam antibiotics .

Diagnostic values of the measurement of specific Immunoglobulin E to penicillin/aminopenicillin and skin test reagents currently available in Thailand will be comparatively analyzed with the standard skin test reagents.

The measurement of drug-induced interferon-gamma releasing cells will be measured in patients with a history of non-immediate reaction.

Enrollment: 500 patients

Sex: All

Ages: 7+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with a history of beta-lactam hypersensitivity

Exclusion criteria

• Being pregnant
• Having serious medical illnesses

Trial design

500 participants in 1 patient group

Patients with suspected drug allergy

Description:

Patients with a history of hypersensitivity reaction to beta-lactam antibiotics