The Diagnostic Assessment and Intervention Study of Amphetamine Type Stimulus

Shanghai Mental Health Center

Status: Completed

Conditions: Amphetamine Addiction

Treatments: Behavioral: psychological rehabilitation training; Radiation: rTMS 10HZ high frequency stimulation; Radiation: fake rTMS 10HZ high frequency stimulation; Behavioral: physical and neurological rehabilitation training

Study type: Interventional

Funder types: Other

Identifiers

NCT02285556

MZhao-003

Details and patient eligibility

About

The purpose of this research is to inspire new medical ideas using brain image technology for the treatment of Amphetamine Type Stimulus addition, at the same time lowing the addition damage.

Full description

The study will increase the sample size based on the preliminary work,also, establish drug dependence induced craving associated environmental experiments , by using the multi-lead biofeedback instrument , CogState tester, event-related potentials Recorder and 3.0T high-field magnetic resonance imaging system to record the physiology , electrophysiology and brain changes during craving, taking a subjective self-assessment , clinical observations and physiological responses combined system to evaluate the ATS addiction degree.

Enrollment: 560 patients

Sex: All

Ages: 18 to 49 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• No previous history of any mental disorder meet the DSM-IV diagnosis
• aged 18-49 years old , men and women
• junior high school or higher education
• use of amphetamine-type substances time for more than one year
• cumulative use of amphetamines, substances dose of 50 grams or more.

Exclusion criteria

• Current or past had suffered neurological diseases
• exclusion of antisocial personality disorder and borderline personality disorder
• addicts in addition to other substances in tobacco , coffee, social drinking outside
• AIDS virus (HIV) detection positive patients .

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

---

560 participants in 7 patient groups, including a placebo group

general information

No Intervention group

Description:

use cross-sectional study to collect 1000 ATS abuse or dependence patients' general information and 5 ml blood,get their blood plasma and DNA sample in order to explore the possible addict mechanism.

ATS diagnosis and evaluation for abusers

No Intervention group

Description:

Use cohort study design to establish ATS abuse induced craving experiment.Do the initial and follow-up assessment from start smoking to stop smoking after 4 weeks, 12 weeks, 26 weeks, 52 weeks and 26 weeks of returning to the community . Thus compare with normal group to explore the possible psychological abuse mechanism.

psychological training intervention

Active Comparator group

Description:

The main content is self-awareness training, social and moral strengthening, impulse control training , problem solving training , situational awareness training , HIV prevention, social skills training under the family atmosphere , family social skills training , interpersonal skills training, community interaction skills training , psychiatric symptoms of self-monitoring skills training and so on.

Treatment:

Behavioral: psychological rehabilitation training

brain stimulation intervention

Active Comparator group

Description:

Use randomized, prospective pseudo stimulus controlled clinical trial design, evaluation of repetitive transcranial magnetic stimulation of the left frontal lobe dorsal lateral effect on ATS dependent induced cognitive dysfunction and other symptoms.

Treatment:

Radiation: rTMS 10HZ high frequency stimulation

ATS diagnosis and evaluation for normal people

No Intervention group

Description:

Do the same initial and follow-up assessment as ATS abusers who stop smoking after 4 weeks, 12 weeks, 26 weeks, 52 weeks and 26 weeks of returning to the community .

physical and neurological rehabilitation

Active Comparator group

Description:

The main content is drug rehabilitation exercise and functional physical training. Rehabilitation led by the discipline cadres , practice once a day, each lasting about 15 minutes .

Treatment:

Behavioral: physical and neurological rehabilitation training

fake brain stimulation intervention

Placebo Comparator group

Description:

fake transcranial magnetic stimulation of the left frontal lobe dorsal lateral effect on ATS dependent induced cognitive dysfunction and other symptoms.

Treatment:

Radiation: fake rTMS 10HZ high frequency stimulation