The Diagnostic Value of Autoimmune Antibody Detection in Newly Onset and Chronic Epilepsy

A

Air Force Military Medical University of People's Liberation Army

Status

Unknown

Conditions

Epilepsy

Study type

Observational

Funder types

Other

Identifiers

NCT04516590
XijingH Deng Yanchun-1

Details and patient eligibility

About

multi-central and prospectively study the diagnostic value of autoimmune antibody detection in new and chronic epilepsy, and provide reference for clinical practice

Full description

multi-centrally recruit patients with newly onset or chronic epilepsy and hoping to find whether there exist an autoimmune cause. whether the patients receive immune therapy or not will depend on the type and titter of the autoimmune antibody as well as the severity of the symptom. At 3 and 6 months later, all patients will be followed-up, and the positive autoimmune antibody will be redetected. the clinical manifest, clinical data, medication and treatment outcome will be recorded and analyzed, to study the diagnostic value of autoimmune antibody detection in new and chronic epilepsy

Enrollment

130 estimated patients

Sex

All

Ages

16 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Patients diagnosed with epilepsy according to the diagnostic criteria of International League Against Epilepsy (ILAE) 2017
  • Age from 16 to 70 years old
  • The etiology of patients with epilepsy is unknown
  • The patient or guardian signs an informed consent and can cooperate with the inspection and follow-up for six months

Exclusion criteria

  • Patients with hereditary, infectious, and metabolic epilepsy
  • The investigation and follow-up cannot be completed due to vision, hearing, language expression, disturbance of consciousness, and impaired understanding, and the guardian cannot replace the completed
  • Patients with other progressive or systemic diseases

Trial design

130 participants in 2 patient groups

autoimmune antigen negative
Description:
treated with anti-epilepsy drugs
autoimmune antigen positive
Description:
whether the patients receive immune therapy or not will depend on the type and titter of the autoimmune antibody as well as the severity of the symptom

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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