The Diagnostic Value of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU

Peking University

Status: Not yet enrolling

Conditions: Acute Kidney Injury; Intensive Care Unit; Ultrasound

Treatments: Diagnostic Test: Contrast-enhanced Ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT06353659

M2024077

Details and patient eligibility

About

The goal of this observational study is to quantitatively assess the renal microcirculation changes by contrast-enhanced ultrasound (CEUS) and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore the diagnostic value of CEUS in critically ill acute kidney injury.

Full description

The main questions it aims to answer are:

1. To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation。
2. To explore the relationship between renal microcirculation and systemic hemodynamics。
3. To explore the value of quantitative evaluation of renal microcirculation changes by contrast-enhanced ultrasound in the diagnosis of acute kidney injury

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age>18 years old
• First admission to ICU < 24h after admission and expected ICU stay ≥48 hours
• Acute kidney injury risk factors (KDIGO 2012)
• Contrast-enhanced ultrasound

Exclusion criteria

• Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment
• Kidney transplantation or renal malignancy
• Terminal stage of malignant tumor
• Pregnancy
• Renal artery stenosis or renal vein thrombosis
• The quality of CEUS images is poor, and quantitative analysis cannot be performed

Trial design

60 participants in 2 patient groups

Patients with acute kidney injury (AKI)

Description:

Patient diagnosed with AKI according to kidney disease improving global outcomes (KDIGO) 2012 criteria

Treatment:

Diagnostic Test: Contrast-enhanced Ultrasound

Patients without AKI

Description:

Patient diagnosed without AKI according to kidney disease improving global outcomes (KDIGO) 2012 criteria

Treatment:

Diagnostic Test: Contrast-enhanced Ultrasound