The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane

Sun Yat-sen University

Status: Completed

Conditions: Cerebral Hypoxia; Postoperative Cognitive Dysfunction

Treatments: Procedure: propofol; Procedure: sevoflurane

Study type: Observational

Funder types: Other

Identifiers

NCT01757561

伦审[2012]324号

Details and patient eligibility

About

the purpose of this study is to investigate whether propofol and sevoflurane have difference effect on cerebral oxygenation .

Full description

the purpose of this study:(1) to investigate the incidence of preoperative cerebral oxygenation abnormity (SjvO2 <55%) and its relationship with intraoperative cerebral desaturation and POCD. (2) To investigate the change of intraoperative cerebral oxygen supply and demand balance and the incidence of cerebral desaturation in patients with abnormal preoperative cerebral oxygenation during sevoflurane anesthesia. (3)To investigate the incidence of early POCD in patients with abnormal preoperative cerebral oxygenation during sevoflurane and propofol anesthesia.

Enrollment: 144 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• scheduled to take major surgery under general anesthesia over 18 years old classified as ASA class three or less

Exclusion criteria

• have a diagnosis of cerebrovascular disorder

Trial design

144 participants in 4 patient groups

Propofol-Abnormal

Description:

patients with preoperative SjvO2\<55%,using the TIVA technology with propofol,

Treatment:

Procedure: propofol

Propofol-Normal

Description:

patients with preoperative SjvO2≥55%,using the TIVA technology with propofol,

Treatment:

Procedure: propofol

Sevoflurane-Abnormal

Description:

patients with preoperative SjvO2\<55%,using the VIMA technology with sevoflurane,

Treatment:

Procedure: sevoflurane

Sevoflurane-Normal

Description:

patients with preoperative SjvO2≥55%,using the VIMA technology with sevoflurane,

Treatment:

Procedure: sevoflurane