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The Difference in Presentation Level of Variant Receptors in Female Breast Tissue in Macromastia and Micromastia

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National Taiwan University

Status and phase

Unknown
Phase 1

Conditions

Aging

Treatments

Procedure: obtain surgical specimen for analysis

Study type

Interventional

Funder types

Other

Identifiers

NCT00173251
9461700605

Details and patient eligibility

About

There are more and more macromastic women in Taiwan, which may due to the high cholesterol foods. Patients with macromastia not only suffered from physical problems but also psychological discomforts.

Full description

Large breasts cause neck and back pain, irritating grooves, cut in the skin of the shoulders by the pressure of brassiere straps, breast pain, and maceration and dermatoses in the inframammary region. From a psychological point of view, excessively large breasts can be troublesome focus of embarrassment for the teenager as well as the woman in her senior years. Unilateral hypertrophy with asymmetry heightens embarrassment. Thus, patients seek to reduce the size of their breasts.

In the human female, variant receptors were detected in epithelial cells in normal breast tissue, benign breast lesions, breast carcinoma tissue, and breast cancer cell lines2-11. The cause of the difference in breast development status is still unclear. Abnormalities at the tissue receptor level may be important in the pathophysiology of macromastia. This study aimed to make clear the difference in variant receptor levels between breast hypertrophy patients and macromastia ones by examining the receptor levels in breast tissue. Then, we could explore the possible etiology of mammary hypertrophy and macromastia.

Sex

All

Ages

20 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • patients receiving reduction mammoplasty

Exclusion criteria

Trial design

Primary purpose

Educational/Counseling/Training

Allocation

Non-Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

Trial contacts and locations

0

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Central trial contact

Hao-Chih Tai, M.D.

Data sourced from clinicaltrials.gov

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