The Difference of Grey Matter Volume Among the Patients of Schizophrenia

Shanghai Mental Health Center

Status: Completed

Conditions: Schizophrenia; Neuroimaging; Cognitive Dysfunction

Treatments: Other: This is not an intervention study

Study type: Observational

Funder types: Other

Identifiers

NCT05262790

GMV-2013

Details and patient eligibility

About

Schizophrenia is a heritable complex phenotype whose symptoms can be clustered into three domains: positive symptoms, negative symptoms and cognitive impairments. Constellations of negative symptoms in SCZ are composed of diminished motivation and pleasure, such as asociality, anhedonia, and avolition, or diminished expressivity such as blunted affect and alogia. Negative symptoms are associated with decreased quality of life and poor functional outcomes. Although antipsychotics are generally effective on positive symptoms, they are poorly effective on negative symptoms Currently, there are no licensed targeted medications for negative symptoms. In view of these problems, considerable interest in identifying new treatment targets for negative symptoms has grown over the past decade. Despite intense efforts in brain imaging that have opened new opportunities for addressing these issues, the neurobiological mechanism of negative symptoms remains unclear.

Structural brain measures from magnetic resonance imaging (MRI) are highly heritable and representatively have high reproducibility and low measurement error. Prior neuroimaging researches have consistently shown neuroanatomical abnormalities in the brains of individuals with SCZ, with the most robust and consistent group-level structural differences in widespread reduced volumes of hippocampal thalamus, amygdala and nucleus accumbens. SCZ have been associated with widespread structural brain abnormalities, but results from neuroimaging studies have been inconsistent.

Full description

Schizophrenia (SCZ) is a heritable complex phenotype whose symptoms can be clustered into three domains: positive symptoms, negative symptoms and cognitive impairments. Constellations of negative symptoms in SCZ are composed of diminished motivation and pleasure, such as asociality, anhedonia, and avolition, or diminished expressivity such as blunted affect and alogia. Negative symptoms are associated with decreased quality of life and poor functional outcomes. Although antipsychotics are generally effective on positive symptoms, they are poorly effective on negative symptoms Currently, there are no licensed targeted medications for negative symptoms. In view of these problems, considerable interest in identifying new treatment targets for negative symptoms has grown over the past decade. Despite intense efforts in brain imaging that have opened new opportunities for addressing these issues, the neurobiological mechanism of negative symptoms remains unclear.

Structural brain measures from magnetic resonance imaging (MRI) are highly heritable and representatively have high reproducibility and low measurement error. Prior neuroimaging researches have consistently shown neuroanatomical abnormalities in the brains of individuals with SCZ, with the most robust and consistent group-level structural differences in widespread reduced volumes of hippocampal thalamus, amygdala and nucleus accumbens. SCZ have been associated with widespread structural brain abnormalities, but results from neuroimaging studies have been inconsistent.

Enrollment: 253 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All the patients satisfied the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-Ⅳ) diagnostic criteria for schizophrenia or schizophreniform disorder.
• Women and men
• 18 to 60 years of age
• Able and willing to provide written informed consent; and willing to commit to the study protocol
• Able to read, speak, and understand Chinese

Exclusion criteria

• (i) were <18 years or >60 years
• (ii) psychotic patients in unstable clinical condition (e.g., being aggressive and uncooperative)
• (iii) had major neurological or other psychiatric disorders, or significant medical condition including neurological disease, severe cardiovascular, hepatic, renal diseases
• (iv)had MRI abnormalities, or had MRI contraindications.

Trial design

253 participants in 3 patient groups

PNS group

Description:

The patients with prominently negative symptoms (PNS) had a greater score on the negative than on the positive subscale of the PANSS, a negative symptoms score \> 20, and at least one of items from PANSS negative symptoms scale ≥ 4 points

Treatment:

Other: This is not an intervention study

Other: This is not an intervention study

Other: This is not an intervention study

PPS group

Description:

The patients with predominantly positive symptoms (PPS) had a greater score on the positive than on the negative subscale of the PANSS

Treatment:

Other: This is not an intervention study

Other: This is not an intervention study

Other: This is not an intervention study

Control

Description:

Healthy control

Treatment:

Other: This is not an intervention study

Other: This is not an intervention study

Other: This is not an intervention study