The Different Analgesic Potency of Volatile Anesthetics at Equi-MAC

Kangbuk Samsung Hospital

Status and phase

Completed

Phase 3

Conditions

Orthopedic Disorders

Treatments

Drug: Desflurane

Drug: Sevoflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT02609802

2015-09-028

Details and patient eligibility

About

The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

Full description

Volatile anesthetics vary in their relative hypnotic potencies. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetics produced different EEG-derived indices such as bispectral index. However, there was no controlled study that demonstrates the difference of analgesic potency. The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

Enrollment

77 patients

Sex

All

Ages

19 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients undergoing arthroscopic shoulder surgery
patients with american society of anesthesiologist physical status I, II
patients aged 19-65 years
patients obtaining written informed consent

Exclusion criteria

patients with a history of any psychiatric or neurological disease
patients who had received any medication affecting the central nervous system
patients who had received medication affecting the sympathetic or parasympathetic nervous systems
patients who have not received interscalene approach brachial plexus block (refusal or failure)
pregnant women