The Different Response of Endocrine Hormones to Hypoglycemia in Patients With Type 1 or Type 2 Diabetes

Nanjing Medical University

Status

Completed

Conditions

Diabetes

Treatments

Diagnostic Test: The hyperinsulinaemic hypoglycaemic clamp

Study type

Observational

Funder types

Other

Identifiers

NCT05290207

KY20220124-07

Details and patient eligibility

About

Endocrine hormones, not only blood glucose responsive hormones, but also sexual hormones, thyroid hormones, growth hormones and so on, may have response and activites in hypoglycemia. However, the different responses of endocrine hormones to hypoglycemia in patients With diabetes remain unclear.

Full description

This study will observe the changes of insulin, C-peptide, glucagon, growth hormone, IGF-1, ACTH, cortisol, thyroid function, sexual hormone in newly diagnosed men with type 2 and type 1 diabetes mellitus using hyperinsulinaemic hypoglycaemic clamp technique

Enrollment

35 patients

Sex

Male

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients

newly diagnosed male patients with type 1 or type 2 diabetes (diagnostic criteria of World Health Organization)
aged 18-50 years
has not been treated with any hypoglycemic drugs
HbA1c>9% Normal subjects: healthy and had no known illness

Exclusion criteria

patients with insulin allergy.
any history of hypoglycemic agent intake or were presently taking hypoglycemic agents
any abnormality in liver or kidney function on blood and urine investigations
any history of systemic corticosteroid use in 3 months
any recent infections or acute medical events
any other obvious conditions or associated diseases determined by the researcher: such as severe cardiopulmonary diseases, endocrine diseases, neurological diseases, tumors and other diseases, other pancreatic diseases, history of mental diseases.