The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers (Nanoexposure)

Tel Aviv Sourasky Medical Center

Status: Unknown

Conditions: Inadequate or Impaired Respiratory Function

Study type: Observational

Funder types: Other

Identifiers

NCT01599845

TASMC-11-YS-0107-CTIL

Details and patient eligibility

About

Investigation of the differences between the levels of extracellular and intracellular nano-particles in workers exposed to environmental particles during their employment to enhance understanding the process of penetration of the particles to respiratory epithelial cells.

Full description

This study investigates the following questions:

Does occupational exposure to nanoparticles influence permeation of such particles to respiratory airways? Is there a correlation between the levels of nanoparticles in sample biological fluids of the patients and their pulmonary functions.

Is there a correlation between the levels of nanoparticles in sample biological fluids of the patients and respiratory tract infections.

The study protocol includes the following steps:

Initial interview of the patient Measurement of nanoparticles in samples of exhaled breath condensate using NanoSight LM 20 Measurement of nanoparticles in induced sputum. And finally examination of the relationship between the measured parameters and the indices of pulmonary infection, and pulmonary function as measured by the pulmonary department of the TASMC.

Enrollment: 60 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults over 20 years of age who visit Ichilov Hospital for medical complaints/inquiries regarding respiratory tract.
• Study population is composed of people who are exposed to environmental particles form industrial sources.
• Informed consent is requested from each subject.

Exclusion criteria

• Unemployed individuals.
• Individuals who are not working in industrial jobs, such as office workers and secretaries.

Trial design

60 participants in 1 patient group

Nanoparticle exposed