The Discovery of the Double Sphincter in Gallbladder

Guangzhou Medical University

Status and phase: Unknown; Phase 4

Conditions: Gallstone

Treatments: Drug: Tauroursodeoxycholic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT01998451

GYGDWK-03

Details and patient eligibility

About

We found a new Double sphincter which located in the neck of gallbladder，we supposed it may be related to control pressure of bile duct.Its formation is related to genetic factors.

Full description

To contrast the recurrence rate of gallstones between patients with gallbladder double sphincter and patients with general gallbladder sphincter who underwent the treatment of cholecystolithiasis by minimally invasive cholecystolithotomy with gallbladder reservation. Method:Patients with gallbladder double sphincter and patients with general gallbladder sphincter who underwent the treatment of cholecystolithiasis by minimally invasive cholecystolithotomy with gallbladder reservation in The Affiliated Hospital of Guiyang Medical College from May 2012 to December 2015. We collect these patients' bile during surgery.Patients with gallbladder double sphincter as trial group, patients with general gallbladder sphincter as control group.the overall follow-up period is 3 years. Then the investigators statistically analyze improvement of cholecystolithiasis symptoms, thickness of gall bladder wall, the gallbladder function and the rate of the recurrence of cholesterol gallstone in 2 groups.we also analysis of the genetic differences from bile between two groups.

Enrollment: 150 estimated patients

Sex: All

Ages: 15 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• people with gallbladder double sphincter

Exclusion criteria

• people without gallbladder double sphincter

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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150 participants in 2 patient groups

Double sphincter group

Experimental group

Description:

patients from double sphincter group all received Tauroursodeoxycholic acid after surgery for 6 months.

Treatment:

Drug: Tauroursodeoxycholic acid

general gallbladder sphincter group

Other group

Description:

patients from general gallbladder sphincter group all received Tauroursodeoxycholic acid after surgery for 6 months.

Treatment:

Drug: Tauroursodeoxycholic acid