The Disease Progression of Chinese Axial Spondyloarthritis in a Real-word Cohort Study (DPCASPA)

China-Japan Friendship Hospital

Status: Enrolling

Conditions: Ankylosing Spondylitis (AS); Axial Spondyloarthritis

Study type: Observational

Funder types: Other

Identifiers

NCT06844643

2023-NHLHCRF-YYPPLC-TJ-02

Details and patient eligibility

About

An observational, ambispective cohort to learn about the disease progression of axial spondyloarthritis (axSpA) according to the changes from baseline in measures of disease activity, function, and imaging.

Full description

This is an observational cohort study of Chinese patients (≥18 years of age) diagnosed with axSpA. Patients are followed at 4-6 month intervals. Data will be collected at baseline and at every follow-up time points. Primary outcomes are the structural damage measured with imaging(Conventional radiography, low-dose CT and MRI) and the disease activity measured with the Ankylosing Spondylitis Disease Activity Scale (ASDAS) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Secondary outcomes are inflammatory markers, Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI).

Enrollment: 2,250 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18 years or older and diagnosed with the Assessment of Spondyloarthritis International Society axial spondyloarthritis criteria.

Exclusion criteria

• Patients with serious disease in cardiovascular, kidney and blood and endocrine system; history of schizophrenia or epilepsy; pregnant or in lactation period.