The Diversity of the Fungal and Bacterial in Colon Mucosa of Patients With Different Degree of Inflammation of Ulcerative Colitis

Xiuli Zuo

Status: Unknown

Conditions: Ulcerative Colitis

Treatments: Other: ulcerative colitis; Other: Control

Study type: Observational

Funder types: Other

Identifiers

NCT03151850

2015SDU-QILU-G004

Details and patient eligibility

About

We analyzed the diversity of the fungal and bacterial within colon mucosa between patients with different degree of inflammation of Ulcerative Colitis.

Full description

In recent years, the relationship of intestinal fungus with inflammatory bowel disease was gradually revealed. We divided the patients with ulcerative colitis into three groups on the basis of World Gastroenterology Organisation (WGO) classification about inflammation degree and progress classification and established the healthy control group. Analyzing the diversity of the fungal and bacterial within colon mucosa between patients with different clinical classification, for example, the proportion of bacteria and fungi, the proportion of candida albicans, the proportion of yeasts, and so on.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients at our tertiary care medical center, aged between 18 and 80 years, scheduled to undergo surveillance colonoscopy.
• The patients with ulcerative colitis for ulcerative colitis group.
• The patients without ulcerative colitis for control group.
• 18-80 years.

Exclusion criteria

• Using antibiotics, glucocorticoid and immunosuppressants wintin one month.
• There are contraindications for enteroscopy and biopsy.
• There are other intestinal diseases.
• Pregnancy or breast-feeding women.
• Patients with serious lung disease and mental illness.

Trial design

50 participants in 2 patient groups

ulcerative colitis

Description:

We analysed the diversity of the fungal and bacterial in patients with Ulcerative Colitis (UC). We take 2 pieces of biopsies in the sigmoid colon mucosa inflammation area during the colonoscopy and then perform gene sequencing.

Treatment:

Other: ulcerative colitis

Control

Description:

Analysing the diversity of the fungal and bacterial in patients without ulcerative colitis. We take 2 pieces of biopsies in the sigmoid colon mucosa during the colonoscopy and then perform gene sequencing.

Treatment:

Other: Control