The DNA Methylation of ARHGEF11 in Macrosomia

Peking University

Status: Completed

Conditions: Gestational Diabetes; Diabetes; Macrosomia, Fetal

Treatments: Diagnostic Test: OGTT

Study type: Observational

Funder types: Other

Identifiers

NCT03165643

2013572

Details and patient eligibility

About

Background Macrosomia at birth is associated with subsequent susceptibility to obesity, abnormal glucose metabolism, hypertension and dyslipidaemia. Epigenetic reprogramming has been reported to be involved in the development of human diseases caused by suboptimal environmental or nutritional factors.

Objective The study was aiming to explore epigenetic mechanism influences on macrosomic infants exposed to intrauterine hyperglycemia.

Design The investigators performed a genome-wide analysis of DNA methylation in cord blood from macrosomic infants born to women with gestational diabetes or infants with normal birth weight born to normal glucose-tolerant women in order to identify genes related to foetal growth or early adipose tissue development. The candidate genes were then validated using SEQUENOM MassARRAY after bisulfite conversion.

Enrollment: 239 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

Exclusion criteria

• Pregnancies complicating with hypertensive disorders, pre-gestational diabetes, thyroid diseases, renal dysfunction were excluded.

Trial design

239 participants in 4 patient groups

NGT-normal birth weight

NGT-macrosomia

GDM-normal birth weight

Treatment:

Diagnostic Test: OGTT

GDM-macrosomia

Treatment:

Diagnostic Test: OGTT