The Dose of Sugammadex for Rapid Reversal of Profound Neuromuscular Block in Young and Elderly Patients

Yonsei University

Status: Completed

Conditions: Anesthesia Recovery Period, Neuromuscular Blockade

Treatments: Drug: Sugammadex

Study type: Interventional

Funder types: Other

Identifiers

NCT01890057

4-2013-0280

Details and patient eligibility

About

To find out the dose of sugammadex for recovery of the TOF ratio to 0.9 within 2 minutes from profound rocuronium-induced neuromuscular block in young and elderly adult patients.

Full description

A previous study reported that elderly patients required a longer time to recover from rocuronium induced neuromuscular block compared to younger patients. Therefore, the aim of this study is to find out the dose of sugammadex for rapid recovery from profound neuromuscular block in young and elderly adult patients.

Enrollment: 44 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 20-40 years or ≥70 years ASA class I-II patients who received surgery less than 2 hours.

Exclusion criteria

• anticipated difficult intubation
• neuromuscular, hepatic or renal disorders
• drug allergy
• body mass index >30 kg/m2 or body mass index <18 kg/m2
• emergency surgery

Trial design

44 participants in 2 patient groups

Young adults

Experimental group

Description:

To find out the the dose of sugammadex for recovery of the TOF ratio to 0.9 within 2 minutes from profound neuromuscular block : Dixon's up-and-down method

Treatment:

Drug: Sugammadex

Elderly adults

Experimental group

Description:

To find out the the dose of sugammadex for recovery of the TOF ratio to 0.9 within 2 minutes from profound neuromuscular block : Dixon's up-and-down method

Treatment:

Drug: Sugammadex