The Dual Impact of Homocysteine and Cholesterol on Cognitive Functions

Assiut University

Status: Completed

Conditions: Hyperhomocysteinemia; Hypercholesterolemia; Cognitive Dysfunction

Treatments: Diagnostic Test: Blood sampling for total cholesterol and homocysteine and cognitive assessment by psychometric tests.

Study type: Observational

Funder types: Other

Identifiers

NCT03631238

Cholesterol and cognition

Details and patient eligibility

About

The study evaluates if the relationship between total serum cholesterol is dependent on the total serum homocysteine. Fasting blood samples will taken from participants and two batteries of cognitive scales will be used to asses any cognitive decline.

Full description

The relationship between total serum cholesterol (TC) levels and cognition remains wily.

Some studies suggested that high TC level in old peoples is associated with a decreased risk of dementia.

Other studies have indicated that hypercholesterolemia may be a risk factor for cognitive decline and Alzheimer's disease (AD).

But a recent study published in 2014 by Cheng and colleagues, showed that, an inverse U-shaped relationship between total cholesterol level and cognitive score was found only in participants with normal homocysteine levels. Indicating that both low and high total serum cholesterol were associated with lower cognitive scores, ended to the relationship between cholesterol levels and cognitive function depends upon homocysteine levels, suggesting an interactive role between cholesterol and homocysteine on cognitive function in the elderly peoples.

The effect of high serum homocysteine (HHcy) levels on cognition was overwhelming regardless of the serum cholesterol levels but in peoples with normal homocysteine levels, both low and high cholesterol levels may be detrimental to cognitive health.

Enrollment: 41 patients

Sex: All

Ages: 55+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Fifty hundred participants
• Participants are of both genders
• Aged 55 years old and over.

Exclusion criteria

• Patient with dementia.
• Renal and hepatic impairment.
• Parkinson's disease.
• Cerebrovascular stroke.
• Patient with chronic medical problems.
• Patients on statins.

Trial design

41 participants in 1 patient group

Apparently normal participants

Description:

Participants are not complaining from any cognitive decline are subjected to cognitive and cholesterol and homocysteine levels assessment.

Treatment:

Diagnostic Test: Blood sampling for total cholesterol and homocysteine and cognitive assessment by psychometric tests.