The Early Rehabilitation Program in Post-LT Pts

Asan Medical Center

Status: Completed

Conditions: ICU-acquired Weakness

Treatments: Behavioral: Early rehabilitation program for liver transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT03529656

AsanMC-LT rehab

Details and patient eligibility

About

The purpose of this study is to determine whether an early rehabilitation program for immediate liver transplant patients is safe and effective in preventing critical care illness and intensive care unit acquired weakness.

Full description

Patients with liver transplantation (LT) have poor general condition before surgery and require ICU care for a certain period. For those patients, the side effects of ICU care such as intensive care unit-acquired weakness (ICU-AW), critical illness polyneuropathy (CIP) are well known. Therefore, we access the safety and efficacy of early rehabilitation program (ERP) in liver transplant recipients.

Patients were retrospectively selected for the Pre-ERP group (2014.05-2014.10) and for the Post-ERP group (2015.10-2016.03). During the period of 6 months, 136 patients and 100 patients underwent LT, and 65, 62 patients were enrolled after exclusion. Forty patients from the each group were compared after propensity score matching (PSM).

Enrollment: 236 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• immediate post liver transplant patients

Exclusion criteria

• patients who transferred to sub-ICU within 72 hours re-liver transplantation case wound, mental problem post op bleeding unstable vital

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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236 participants in 2 patient groups

Pre-ERP

No Intervention group

Description:

A group of patients who underwent liver transplantation surgery before the early rehabilitation program

Post-ERP

Experimental group

Description:

A group of immediate liver transplant patients who had an early rehabilitation program in ICU care

Treatment:

Behavioral: Early rehabilitation program for liver transplantation