The EC50 of Remifentanil Blunting Hemodynamic Response to Double Lumen Tube Intubation

Seoul National University

Status: Completed

Conditions: Hemodynamic Responses During Tracheal Intubation

Treatments: Drug: Remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT01542099

JHBahk_DLT_remi

Details and patient eligibility

About

The purpose of this study is to evaluate the effect site concentration of remifentanil blunting hemodynamic changes to tracheal intubation of single or double lumen tubes.

Enrollment: 80 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing thoracic surgery that require one lung ventilation

Exclusion criteria

• patient who does not agree with this study
• BMI < 16.0 or BMI > 30
• cardiovascular disease, pulmonary disease, renal disease
• alcoholic abuser or drug abuser
• patient who takes any drug to influence cardiovascular system or sympathetic nervous system
• any use of local anesthetics or drugs to influence cardiovascular system during tracheal intubation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

Single lumen tube

Active Comparator group

Description:

Single lumen tube intubation during remifentanil infusion

Treatment:

Drug: Remifentanil

Drug: Remifentanil

Double lumen tube

Active Comparator group

Description:

Double lumen tube intubation during remifentanil infusion

Treatment:

Drug: Remifentanil

Drug: Remifentanil