The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation

Seoul National University

Status: Completed

Conditions: ICH; Brain Tumor; AVM

Treatments: Drug: remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT01489137

JHBahk_fixation_remifentanil

Details and patient eligibility

About

The purpose of this study is to estimate the EC90 of remifentanil blunting hemodynamic changes to head fixation in the patients undergoing neurosurgery.

Enrollment: 50 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing neurosurgery that require head fixation with mayfield head holder
• patients who agree to our study

Exclusion criteria

• patients who don't agree to our study
• BMI<16.0 or BMI>30
• cardiovascular disease, pulmonary disease, renal disease
• alcoholic abuser or drug abuser
• patients who takes any drug having an influence on cardiovascular system or sympathetic nervous system
• any use of local anesthetics or drugs which have an influence on cardiovascular system from beginning of induction to peri-fixation period

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

neurosurgery with fixation

Experimental group

Treatment:

Drug: remifentanil