Status and phase
Conditions
Treatments
About
Dexmedetomidine(DEX) could provide dose-dependent sedation , analgesia , anti-anxiety and inhibition of sympathetic nerves and other effects. Because of its minimal impact on the respiratory , currently it was more and more widely used to sedate patients undergoing regional anesthesia.Many anesthetic pharmacokinetics and pharmacodynamics are often affected by age, and current studies with regard to the effects of age on dexmedetomidine pharmacodynamic are rare. This study was designed to explore the right DEX dose of different female Age of patients to produce suitable sedation.Dexmedetomidine be used in patients with combined spinal and epidural anesthesia for sedation,which is monitored by the Narcotrend,during the operation.The relation between Narcotrend index (NTI) and the depth of sedation for patients is also investigated.
Full description
90 patients scheduled for combined spinal epidural spinal anesthesia were included in one of three groups. In each group,determination of median effective (ED50) doses was performed by the Dixon up-and-down method, an initial dose of 1.0 μg/kg dexmedetomidine, with dose adjustment intervals of 0.1 μg/kg in first three turning points and 0.05μg/kg in the last three turning points.Initial doses was 1.4μg/kg, .Sedative efficacy was defined as an OAA/S of ≤3,30 min after the beginning of drug administration.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Exclusion criteria
Mental illness can not match
epidural anesthesia contraindicated
People who have Slow-type arrhythmias
People who were language or hearing impaired
Sensory block reached to T8 or higher.
People who had lung infection or sleep apnea syndrome.
Pregnancy
Chronic renal failure
Alcohol or drug abuse
Already taking gabapentin, pregabalin, benzodiazepin or antidepression drug
Primary purpose
Allocation
Interventional model
Masking
90 participants in 3 patient groups
Loading...
Central trial contact
Bo Xu
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal