The Edi Level and Cardiopulmonary Function Between HHHFNC and Unheated Humidified High-Flow Oxygen Mask in COPD

Fu Jen Catholic University

Status: Terminated

Conditions: Respiratory Insufficiency; Chronic Obstructive Lung Disease

Treatments: Device: UHFOM; Device: HHHFNC

Study type: Interventional

Funder types: Other

Identifiers

NCT03811158

PL-201705001-M

Details and patient eligibility

About

Patients with COPD exacerbation usually need respiratory support after extubation. Recently, HHHFNC has been used in both adult and neonates with post-extubation respiratory support. Studies indicate that HHHFNC has seminar efficacy compared to non-invasive positive pressure ventilation and superior than conventional oxygen therapy. There are no clinical data of diaphragm electrical activity and cardiopulmonary function for using HHHFNC and UHFOM as post-extubation respiratory support.

Full description

Objectives： The aim of this study is to compare the Edi level and cardiopulmonary parameters between heated humidified high-flow nasal cannula (HHHFNC) versus unheated high-flow oxygen mask (UHFOM) in acute exacerbation of chronic obstructive pulmonary disease (COPD) patients with post-extubation respiratory support. This is the first clinical trial to investigate and analysis the variations of cardiopulmonary parameters and Edi level between HHHFNC and UHFOM in adult patients.

Enrollment: 2 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. AE of COPD received intubation and ready to be weaning
2. P/F ratio > 200 during SBT before extubation

Exclusion criteria

1. Unable to insert NG tube
2. Refuse to re-intubated when respiratory failure after extubation
3. Planned NIV use after extubation
4. Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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2 participants in 2 patient groups

HHHFNC group

Experimental group

Description:

On HHHFNC FiO2 will setting as same as SBT before extubation Flow rate: 50L/min

Treatment:

Device: HHHFNC

UHFOM group

Sham Comparator group

Description:

On Aerosol mask FiO2 will setting as same as SBT before extubation Flow rate: 15L/min

Treatment:

Device: UHFOM